{"id":5182,"date":"2026-02-10T15:42:56","date_gmt":"2026-02-10T06:42:56","guid":{"rendered":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/?page_id=5182"},"modified":"2026-02-22T11:06:50","modified_gmt":"2026-02-22T02:06:50","slug":"study03","status":"publish","type":"page","link":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/study03\/","title":{"rendered":"\u4eba\u5de5\u77e5\u80fd\u306e\u6d3b\u7528\u306b\u95a2\u3059\u308b\u5b9f\u7e3e"},"content":{"rendered":"\n<h2 class=\"wp-block-heading is-style-line_title2\">\u8da3\u65e8<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p>\u69cb\u9020\u60c5\u5831\u306e\u307f\u3092\u7528\u3044\u3001\u533b\u85ac\u54c1\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u5316\u5b66\u7269\u8cea\u306e\u6bd2\u6027\u4e88\u6e2c\u306e\u7cbe\u5ea6\u3092\u7af6\u3046\u56fd\u969b\u7684\u3067\u5927\u898f\u6a21\u306a\u8a08\u7b97\u6bd2\u6027\u5b66\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\u304c\u300110\u5e74\u4ee5\u5185\u306b\uff12\u56de\u958b\u50ac\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u6b27\u5ddeCadaster Environmental Toxicity Challenge\u304a\u3088\u3073\u7c73\u56fdTox21 Data Challenge\uff09\u3002\u5f53\u7814\u7a76\u5ba4\u306e\u690d\u6ca2\u6559\u6388\u306f\u4e21\u5927\u4f1a\u306b\u304a\u3044\u3066\u5165\u8cde\u3092\u679c\u305f\u3057\u3001\u7279\u306b\uff11\u4e07\u5316\u5408\u7269\u3092\u6295\u5165\u3057\u305f\u53f2\u4e0a\u6700\u5927\u898f\u6a21\u306e\u6bd2\u6027\u4e88\u6e2c\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\u3067\u3042\u308bTox21 Challenge\u3067\u306f\u3001\u5973\u6027\u30db\u30eb\u30e2\u30f3\u69d8\u4f5c\u7528\u3092\u6709\u3059\u308b\u5316\u5408\u7269\u306e\u4e88\u6e2c\u306b\u95a2\u3057\u3066\u512a\u52dd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"vk_block-margin-0--margin-bottom\">\u3053\u308c\u3089\u306e\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\u3067\u4f7f\u7528\u3055\u308c\u308b\u3088\u3046\u306a\u591a\u6570\u306e\u5316\u5408\u7269\u3092\u4e88\u6e2c\u3059\u308b\u5834\u5408\u3001\u5316\u5408\u7269\u3068\u6bd2\u6027\u30fb\u526f\u4f5c\u7528\u306e\u95a2\u4fc2\u306f\u3001\u4eba\u306b\u3088\u308b\u89e3\u91c8\u306e\u9650\u5ea6\u3092\u8d85\u3048\u3066\u975e\u5e38\u306b\u8907\u96d1\u3067\u3059\u3002\u305d\u3053\u3067\u8a08\u7b97\u6bd2\u6027\u5b66\u7684\u89e3\u6790\u3067\u306f\u4eba\u5de5\u77e5\u80fd\u306e\u6280\u8853\u3092\u9069\u7528\u3057\u3066\u4e88\u6e2c\u7cbe\u5ea6\u306e\u5411\u4e0a\u3092\u8a08\u3063\u3066\u3044\u307e\u3059\u3002\u533b\u7642\u5206\u5b50\u89e3\u6790\u5b66\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30e9\u30f3\u30c0\u30e0\u30d5\u30a9\u30ec\u30b9\u30c8\u3001\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u3068\u3044\u3063\u305f\u6a5f\u68b0\u5b66\u7fd2\u6cd5\u306b\u72ec\u81ea\u306e\u5de5\u592b\u3092\u52a0\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u9ad8\u5ea6\u306a\u4e88\u6e2c\u3092\u9054\u6210\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" src=\"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/wp-content\/uploads\/p13.jpg\" alt=\"\" class=\"wp-image-5184\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading is-style-line_title2\">Deep Snap<\/h2>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:auto 27%\"><div class=\"wp-block-media-text__content\">\n<p>\u3000\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u4eba\u5de5\u77e5\u80fd\u3078\u306e\u65b0\u898f\u306a\u5316\u5408\u7269\u60c5\u5831\u5165\u529b\u30b7\u30b9\u30c6\u30e0\u3067\u3042\u308bDeep Snap\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002(1,2,3)<\/p>\n\n\n\n<p>\u3000\u8fd1\u5e74\u3001\u65b0\u898f\u306a\u4eba\u5de5\u77e5\u80fd\u6280\u8853\u3067\u3042\u308b\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u304c\u69d8\u3005\u306a\u5206\u91ce\u306b\u304a\u3051\u308b\u4e88\u6e2c\u306b\u9769\u65b0\u7684\u306a\u6210\u679c\u3092\u3042\u3052\u3066\u3044\u307e\u3059\u3002QSAR\u6bd2\u6027\u4e88\u6e2c\u306b\u304a\u3044\u3066\u3082\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u306f\u9ad8\u5ea6\u306a\u4e88\u6e2c\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306e\u6709\u671b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002\u4e00\u65b9\u3001\u5316\u5b66\u69cb\u9020\u60c5\u5831\u3092\u4eba\u5de5\u77e5\u80fd\u306b\u53d7\u3051\u6e21\u3059\u305f\u3081\u306b\u3001\u5f93\u6765\u306f\u5206\u5b50\u8a18\u8ff0\u5b50\u3092\u7528\u3044\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u65b9\u6cd5\u306f\u5206\u5b50\u69cb\u9020\u3092\u76f4\u63a5\u89e3\u91c8\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u306e\u6027\u80fd\u3092\u5341\u5206\u306b\u6d3b\u304b\u3057\u3066\u306f\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3000\u305d\u3053\u3067\u3001\u5206\u5b50\u5168\u4f53\u306e\u7279\u5fb4\u3092\u753b\u50cf\u30c7\u30fc\u30bf\u3068\u3057\u3066\u5b66\u7fd2\u3055\u305b\u308b\u65b0\u898f\u306a\u69cb\u9020\u60c5\u5831\u5165\u529b\u6cd5\u300cDeep Snap\u300d\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u672c\u6cd5\u3067\u306f\u3001\u5206\u5b50\u306e\u7acb\u4f53\u69cb\u9020\u3092XYZ\u8ef8\u65b9\u5411\u304b\u3089\u64ae\u50cf\u3057\u3066\u753b\u50cf\u30d5\u30a1\u30a4\u30eb\u3092\u591a\u6570\u751f\u6210\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u3092\u753b\u50cf\u89e3\u6790\u5206\u91ce\u3067\u767a\u5c55\u3057\u3066\u3044\u308b\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0\u306b\u5165\u529b\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u5404\u5206\u5b50\u306b\u7d10\u4ed8\u304f\u751f\u7406\u6d3b\u6027\u5024\u306a\u3069\u306e\u8b58\u5225\u306b\u4f7f\u7528\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000Deep Snap\u306e\u6027\u80fd\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001NIH\u304c\u958b\u50ac\u3057\u305fQSAR\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\uff08Tox21 Data Challenge\uff09\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\u652a\u4e71\u5316\u5408\u7269\u306e\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u305f\u691c\u8a3c\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\u4e0a\u4f4d10\u4f4d\u5185\u306b\u5165\u308b\u826f\u597d\u306a\u4e88\u6e2c\u6027\u80fd\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u8a73\u7d30\u306f\u3001\u5f15\u7528\u6587\u732e\uff082, 3\uff09\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002<\/p>\n\n\n\n<p>1)\u690d\u6ca2\u82b3\u5e83\u3001<a href=\"https:\/\/worldwide.espacenet.com\/patent\/search\/family\/065226286\/publication\/EP3627404A1?q=EP%203627404\" target=\"_blank\" rel=\"noreferrer noopener\">\u7279\u958b2019010095(P2019-10095A) :\u4e88\u6e2c\u88c5\u7f6e\u3001\u4e88\u6e2c\u65b9\u6cd5\u3001\u4e88\u6e2c\u30d7\u30ed\u30b0\u30e9\u30e0\u3001\u5b66\u7fd2\u30e2\u30c7\u30eb\u5165\u529b\u30c7\u30fc\u30bf\u751f\u6210\u88c5\u7f6e\u304a\u3088\u3073\u5b66\u7fd2\u30e2\u30c7\u30eb\u5165\u529b\u30c7\u30fc\u30bf\u751f\u6210\u30d7\u30ed\u30b0\u30e9\u30e0<\/a>\uff082021\u5e74\u30fb\u6b27\u5dde\u7279\u8a31\u304c\u6210\u7acb\u3057\u307e\u3057\u305f\uff08\u7279\u8a31\u756a\u53f7EP3627404\uff09\uff09<\/p>\n\n\n\n<p>2) Uesawa Y,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960894X18307078\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;Quantitative structure-activity relationship analysis using deep learning based on a novel molecular image input technique<\/a>, Bioorg Med Chem Lett. 2018 Nov 1;28(20):3400-3403. doi: 10.1016\/j.bmcl.2018.08.032. Epub 2018 Aug 27.<\/p>\n\n\n\n<p>3)\u690d\u6ca2 \u82b3\u5e83\u3001&nbsp;<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/cicsj\/36\/3\/36_51\/_pdf\/-char\/ja\" target=\"_blank\" rel=\"noreferrer noopener\">\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u306b\u5bfe\u3059\u308b\u5206\u5b50\u60c5\u5831\u306e\u65b0\u898f\u5165\u529b\u6cd5\uff1aDeep Snap<\/a>\u3001CICSJ Bulletin\u30012018 \u5e74 36 \u5dfb 3 \u53f7 p. 51-54\u3001\u767a\u884c\u65e5: 2018\u5e74\u3001\u516c\u958b\u65e5: 2018\/12\/24<\/p>\n\n\n\n<p>4) Yasunari Matsuzaka and Yoshihiro Uesawa,&nbsp;<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2019.00065\/full?&amp;utm_source=Email_to_authors_&amp;utm_medium=Email&amp;utm_content=T1_11.5e1_author&amp;utm_campaign=Email_publication&amp;field=&amp;journalName=Frontiers_in_Bioengineering_and_Biotechnology&amp;id=427670\" target=\"_blank\" rel=\"noreferrer noopener\">Optimization of a deep-learning method based on the classification of images generated by parameterized deep snap a novel molecular-image-input technique for quantitative structure\u2013activity relationship (QSAR) analysis<\/a>, Front. Bioeng. Biotechnol., 2019 March&nbsp;28<\/p>\n\n\n\n<p>5)Matsuzaka Y, Uesawa Y,&nbsp;<a href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/19\/4855\/htm\" target=\"_blank\" rel=\"noreferrer noopener\">Prediction model with high-performance constitutive androstane receptor (CAR) using deepsnap-deep learning approach from the tox21 10K compound library<\/a>, Int J Mol Sci, 2019 Sep 30<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"562\" height=\"1024\" src=\"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/wp-content\/uploads\/20181121-562x1024.png\" alt=\"\" class=\"wp-image-5185 size-full\" srcset=\"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/wp-content\/uploads\/20181121-562x1024.png 562w, https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/wp-content\/uploads\/20181121-165x300.png 165w, https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/wp-content\/uploads\/20181121.png 631w\" sizes=\"auto, (max-width: 562px) 100vw, 562px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-vk-blocks-spacer vk_spacer vk_spacer-type-margin-top\"><div class=\"vk_block-margin-md--margin-top\"><\/div><\/div>\n\n\n\n<div class=\"wp-block-group list_box has-vk-color-custom-2-background-color has-background\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading is-style-line_title2\">\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u6210\u679c<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"http:\/\/www.cadaster.eu\/sites\/cadaster.eu\/files\/final_results.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u74b0\u5883\u6bd2\u6027\u4e88\u6e2c\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\u30fbFirst-Pass Winner<\/a><\/li>\n\n\n\n<li>\u60c5\u5831\u8a08\u7b97\u5316\u5b66\u751f\u7269\u5b66\u4f1a2015\u5e74\u5927\u4f1a\u30fb\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u8cde<\/li>\n\n\n\n<li>Tox21 Data Challenge2014\u30fbWinner<\/li>\n\n\n\n<li><a href=\"https:\/\/ncats.nih.gov\/news\/releases\/2015\/tox21-challenge-2014-winners\" target=\"_blank\" rel=\"noreferrer noopener\">NCATS Announces Tox21 Data Challenge Winners<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8da3\u65e8 \u69cb\u9020\u60c5\u5831\u306e\u307f\u3092\u7528\u3044\u3001\u533b\u85ac\u54c1\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u5316\u5b66\u7269\u8cea\u306e\u6bd2\u6027\u4e88\u6e2c\u306e\u7cbe\u5ea6\u3092\u7af6\u3046\u56fd\u969b\u7684\u3067\u5927\u898f\u6a21\u306a\u8a08\u7b97\u6bd2\u6027\u5b66\u30b3\u30f3\u30da\u30c6\u30a3\u30b7\u30e7\u30f3\u304c\u300110\u5e74\u4ee5\u5185\u306b\uff12\u56de\u958b\u50ac\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u6b27\u5ddeCadaster Environmental Toxicit [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-5182","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/pages\/5182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/comments?post=5182"}],"version-history":[{"count":4,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/pages\/5182\/revisions"}],"predecessor-version":[{"id":5546,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/pages\/5182\/revisions\/5546"}],"wp:attachment":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/media?parent=5182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}