{"id":2732,"date":"2023-12-29T17:50:58","date_gmt":"2023-12-29T08:50:58","guid":{"rendered":"https:\/\/u-lab.my-pharm.ac.jp\/~mminfo\/?p=2732"},"modified":"2023-12-29T17:50:58","modified_gmt":"2023-12-29T08:50:58","slug":"%e5%8c%96%e5%ad%a6%e6%a7%8b%e9%80%a0%e3%81%ab%e3%82%88%e3%82%8b%e5%a4%89%e7%95%b0%e5%8e%9f%e6%80%a7%e4%ba%88%e6%b8%ac%ef%bc%94","status":"publish","type":"post","link":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/blog\/2732\/","title":{"rendered":"\u5316\u5b66\u69cb\u9020\u306b\u3088\u308b\u5909\u7570\u539f\u6027\u4e88\u6e2c\uff14\uff1aAmes\u8a66\u9a13"},"content":{"rendered":"<p><a href=\"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wordpress\/blog\/2715\/\">Ames\/QSAR \u56fd\u969b\u30c1\u30e3\u30ec\u30f3\u30b8\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/a>\u306b\u304a\u3051\u308b<span style=\"color: #0000ff;\"><strong>QSAR\u306e\u4e88\u6e2c\u5bfe\u8c61\u306fAmes\u8a66\u9a13\u306e\u4e88\u6e2c\u7d50\u679c<\/strong><\/span>\u3067\u3059\u3002<br \/>\n Ames\u306e\u967d\u6027\uff0f\u9670\u6027\u306e\u8b58\u5225\u6027\u80fd\u304c\u5224\u5b9a\u3055\u308c\u307e\u3059\u306e\u3067\u3001\u53c2\u52a0\u8005\u306f\u967d\u6027\uff0f\u9670\u6027\u8b58\u5225\u30b7\u30b9\u30c6\u30e0\u3092\u4f7f\u7528\u3057\u3066\u3053\u306e\u30b3\u30f3\u30da\u306b\u81e8\u3093\u3067\u3044\u307e\u3059\u3002<br \/>\n \u3055\u3066\u3001QSAR\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308a\u307e\u3059\u306e\u3067\u3001\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u4f7f\u7528\u3055\u308c\u305f<span style=\"color: #ff0000; font-size: 20px;\"><strong>Ames\u8a66\u9a13\u306e\u6982\u8981<\/strong><\/span>\u3092\u307e\u3068\u3081\u3066\u304a\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Ames\uff08\u30a8\u30fc\u30e0\u30b9\uff09\u8a66\u9a13\u306f\u3001\u751f\u80b2\u306b\u7279\u5b9a\u306e\u30a2\u30df\u30ce\u9178\u304c\u5fc5\u8981\u306b\u306a\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u3001\u3082\u3057\u304f\u306f\u5927\u8178\u83cc\u306e\u83cc\u682a\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002<\/p>\n<p>\u6b21\u306e\u3088\u3046\u306a\u83cc\u682a\u3067\u3059\u3002<br \/>\n \u30fb\u30d2\u30b9\u30c1\u30b8\u30f3\u8981\u6c42\u6027\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u5909\u7570\u682a<br \/>\n \u30fb\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u8981\u6c42\u6027\u5927\u8178\u83cc\u5909\u7570\u682a<\/p>\n<p>&nbsp;<\/p>\n<p>\u3061\u306a\u307f\u306b\u3001Ames\u8a66\u9a13\u306b\u4f7f\u7528\u3055\u308c\u308b\u30d2\u30b9\u30c1\u30b8\u30f3\u8981\u6c42\u6027\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u306f\u30cd\u30ba\u30df\u30c1\u30d5\u30b9\u83cc\uff08Salmonella Typhimurium\uff09\u5909\u7570\u682a\u3067\u3059\u3002<strong><span style=\"color: #ff0000;\">\u85ac\u5264\u5e2b\u56fd\u5bb6\u8a66\u9a13\u306b\u3082\u51fa\u3066\u3044\u307e\u3059<\/span><\/strong>\u3002<\/p>\n<p>\u5909\u7570\u539f\u6027\u7269\u8cea\u306b\u3055\u3089\u3055\u308c\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u5909\u7570\u3092\u8d77\u3053\u3057\u305f\u7d30\u83cc\u306e\u4e00\u90e8\u304c\u300c\u5fa9\u5e30\u7a81\u7136\u5909\u7570\u300d\u3092\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n \u3053\u306e\u7a81\u7136\u5909\u7570\u306f\u5143\u306e\u5909\u7570\u3092\u5fa9\u5e30\u3055\u305b\u3001\u7d30\u83cc\u306e\u30a2\u30df\u30ce\u9178\u5408\u6210\u80fd\u529b\u3092\u56de\u5fa9\u3055\u305b\u307e\u3059\u3002<\/p>\n<p>\u5fa9\u5e30\u7a81\u7136\u5909\u7570\u306e\u767a\u751f\u306b\u3088\u308a\u3001\u7d30\u83cc\u306f\u30d2\u30b9\u30c1\u30b8\u30f3\uff08\u3082\u3057\u304f\u306f\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\uff09\u3092\u542b\u307e\u306a\u3044\u57f9\u5730\u4e0a\u3067\u5897\u6b96\u3057\u3001\u30b3\u30ed\u30cb\u30fc\u3092\u5f62\u6210\u3059\u308b\u69d8\u306b\u306a\u308a\u307e\u3059\u3002\u30b3\u30ed\u30cb\u30fc\u306e\u6570\u304c\u591a\u3051\u308c\u3070\u591a\u3044\u307b\u3069\u3001\u88ab\u691c\u7269\u8cea\u306e\u5909\u7570\u539f\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Ames\u8a66\u9a13\u306b\u4f7f\u7528\u3055\u308c\u308b\u83cc\u682a\u306b\u306f\u3044\u304f\u3064\u304b\u7a2e\u985e\u304c\u3042\u3063\u3066\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u7279\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n \u305d\u308c\u3067\u306f\u3001<strong><span style=\"color: #0000ff;\">Ames\/QSAR \u56fd\u969b\u30c1\u30e3\u30ec\u30f3\u30b8\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u304a\u3044\u3066\u4f7f\u7528\u3055\u308c\u305f\u83cc\u682a<\/span><\/strong>\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\n 2nd Project\u306eTable 5\u306b\u3088\u308b\u3068\u3001<br \/>\n TA100\u3001TA1535\u3001TA98\u3001TA1537\u3001WP2uvrA\u306e\uff15\u682a\u3067\u3057\u305f\u3002<br \/>\n \u3053\u308c\u3089\u304cS9mix\u306e\u5b58\u5728\u4e0b\u304a\u3088\u3073\u975e\u5b58\u5728\u4e0b\u3067Ames\u8a66\u9a13\u306b\u4f9b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span style=\"font-size: 12px;\">S9mix\u3068\u3044\u3046\u306e\u306f\u30e9\u30c3\u30c8\u809d\u81d3\u306eS9\u5206\u753b\u306e\u3053\u3068\u3067\u3001\u809d\u30db\u30e2\u30b8\u30cd\u30fc\u30c8\u30929000g\u3067\u9060\u5fc3\u5206\u96e2\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u308b\u4e0a\u6e05\u5206\u753b\u3067\u3059\u3002\u3053\u306e\u5206\u753b\u306b\u306f\u3001\u7d30\u80de\u8cea\u3068\u30df\u30af\u30ed\u30bd\u30fc\u30e0\u306a\u3069\u306e\u7d30\u80de\u5c0f\u5668\u5b98\u306e\u304b\u3051\u3089\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001CYP\u306a\u3069\u306e\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u3092\u5bb9\u6613\u306b\u4f9b\u7d66\u3067\u304d\u307e\u3059\u3002\u591a\u304f\u306e\u5909\u7570\u539f\u6027\u7269\u8cea\u306f\u4ee3\u8b1d\u6d3b\u6027\u5316\u3055\u308c\u3066\u306f\u3058\u3081\u3066\u5909\u7570\u539f\u6027\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001Ames\u8a66\u9a13\u306b\u306fS9mix\u304c\u7528\u3044\u3089\u308c\u308b\u306e\u3067\u3059\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u6b21\u306b\u3001\u4e0a\u8a18\u306e\uff15\u7a2e\u985e\u306e\u682a\u306e\u7279\u5fb4\u3092\u898b\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/kagakutoseibutsu1962\/15\/12\/15_12_811\/_pdf\/-char\/ja\">1<\/a>,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1383571898000060?via%3Dihub\">2<\/a>,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0027510723000258?via%3Dihub\">3<\/a>)<br \/>\n <strong><span style=\"color: #0000ff;\">\u70b9\u7a81\u7136\u5909\u7570<\/span><\/strong>\u306b\u92ed\u654f<br \/>\n <strong><span style=\"color: #ff0000;\">TA100<\/span><\/strong>\uff1a\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u306e\u5fa9\u5e30\u5909\u7570\u682a<br \/>\n <strong><span style=\"color: #ff0000;\">TA1535<\/span><\/strong>\uff1a\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u306e\u5fa9\u5e30\u5909\u7570\u682a<br \/>\n <strong><span style=\"color: #ff0000;\">WP2uvrA<\/span><\/strong>\uff1a\u5927\u8178\u83cc\u306e\u5fa9\u5e30\u5909\u7570\u682a<\/p>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u30d5\u30ec\u30fc\u30e0\u30b7\u30d5\u30c8\u5909\u7570<\/span><\/strong>\u306b\u92ed\u654f<br \/>\n <strong><span style=\"color: #ff0000;\">TA98<\/span><\/strong>\uff1a\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u306e\u5fa9\u5e30\u5909\u7570\u682a<br \/>\n <strong><span style=\"color: #ff0000;\">TA1537<\/span><\/strong>\uff1a\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u306e\u5fa9\u5e30\u5909\u7570\u682a<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u308c\u3089\u306e\uff15\u7a2e\u985e\u306e\u682a\u304c\u00b1S9mix\u6761\u4ef6\u4e0b\u3067Ames\u8a66\u9a13\u306b\u4f9b\u3055\u308c\u307e\u3057\u305f\u306e\u3067\u3001\uff11\u5316\u5408\u7269\u3042\u305f\u308a\uff11\uff10\u7a2e\u985e\u306e\u8a66\u9a13\u7d50\u679c\u304c\u51fa\u3066\u304f\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\n \u3053\u308c\u3089\u306e\u8a66\u9a13\u7d50\u679c\u3088\u308a\u3001\u4e3b\u50ac\u8005\u306f12,134\u5316\u5408\u7269\u306b\u5bfe\u3059\u308b\u5224\u5b9a\u7d50\u679c\u3092\u53c2\u52a0\u8005\u306b\u63d0\u793a\u3057\u307e\u3057\u305f\uff08\u7b2c\uff12\u56de\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Ames\u8a66\u9a13\u306e\u6e2c\u5b9a\u7d50\u679c\u306f\u5316\u5408\u7269\u6bce\u306b\u3001<br \/>\n <strong><span style=\"color: #0000ff;\">\u30af\u30e9\u30b9A\uff08\u5f37\u3044\u5909\u7570\u539f\u6027\u3042\u308a\uff09<\/span><\/strong><br \/>\n <strong><span style=\"color: #0000ff;\">\u30af\u30e9\u30b9B\uff08\u5909\u7570\u539f\u6027\u3042\u308a\uff09<\/span><\/strong><br \/>\n <strong><span style=\"color: #0000ff;\">\u30af\u30e9\u30b9C\uff08\u5909\u7570\u539f\u6027\u306a\u3057\uff09<\/span><\/strong><br \/>\n \u306e\u4e09\u6bb5\u968e\u3067\u5b9a\u7fa9\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n \u305d\u3057\u3066\u3001<strong><span style=\"color: #ff0000;\">\u30af\u30e9\u30b9A\u3068\u30af\u30e9\u30b9B\u304c\u300c\u967d\u6027\u300d<\/span><\/strong>\u3001<span style=\"color: #ff0000;\"><strong>\u30af\u30e9\u30b9C\u304c\u300c\u9670\u6027\u300d<\/strong><\/span>\u3068\u3057\u3066\u63d0\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u7b2c\uff12\u56de\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u53c2\u52a0\u8005\u306f\u3001\u3053\u308c\u3089\u306eAmes\u8a66\u9a13\u306e\u7d50\u679c\u3068\u3068\u3082\u306b\u5225\u9014\u4f9b\u7d66\u3055\u308c\u305f\u5316\u5b66\u69cb\u9020\u60c5\u5831\u3092\u4f7f\u3063\u3066\u967d\u6027\u5316\u5408\u7269\u3068\u9670\u6027\u5316\u5408\u7269\u306e\u8b58\u5225\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u306a\u304a\u3001\u30eb\u30fc\u30eb\u3068\u3057\u3066\u3053\u308c\u4ee5\u5916\u306eAmes\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u306e\u4f7f\u7528\u3082\u8a31\u53ef\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ames\/QSAR \u56fd\u969b\u30c1\u30e3\u30ec\u30f3\u30b8\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u304a\u3051\u308bQSAR\u306e\u4e88\u6e2c\u5bfe\u8c61\u306fAmes\u8a66\u9a13\u306e\u4e88\u6e2c\u7d50\u679c\u3067\u3059\u3002 Ames\u306e\u967d\u6027\uff0f\u9670\u6027\u306e\u8b58\u5225\u6027\u80fd\u304c\u5224\u5b9a\u3055\u308c\u307e\u3059\u306e\u3067\u3001\u53c2\u52a0\u8005\u306f\u967d\u6027\uff0f\u9670\u6027\u8b58\u5225\u30b7\u30b9\u30c6\u30e0\u3092\u4f7f\u7528\u3057\u3066\u3053\u306e\u30b3\u30f3\u30da\u306b\u81e8\u3093\u3067\u3044\u307e\u3059\u3002 [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[18],"tags":[20,21],"class_list":["post-2732","post","type-post","status-publish","format-standard","hentry","category-blog","tag-ames","tag-qsar"],"_links":{"self":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts\/2732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/comments?post=2732"}],"version-history":[{"count":0,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts\/2732\/revisions"}],"wp:attachment":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/media?parent=2732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/categories?post=2732"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/tags?post=2732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}