{"id":2782,"date":"2024-01-08T10:10:07","date_gmt":"2024-01-08T01:10:07","guid":{"rendered":"https:\/\/u-lab.my-pharm.ac.jp\/~mminfo\/?p=2782"},"modified":"2024-01-08T10:10:07","modified_gmt":"2024-01-08T01:10:07","slug":"%e5%8c%96%e5%ad%a6%e6%a7%8b%e9%80%a0%e3%81%ab%e3%82%88%e3%82%8b%e5%a4%89%e7%95%b0%e5%8e%9f%e6%80%a7%e4%ba%88%e6%b8%ac%ef%bc%91%ef%bc%90%ef%bc%9a%ef%bc%88%e6%9c%80%e8%89%af%e3%81%ae%e4%ba%88%e6%b8%ac","status":"publish","type":"post","link":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/blog\/2782\/","title":{"rendered":"\u5316\u5b66\u69cb\u9020\u306b\u3088\u308b\u5909\u7570\u539f\u6027\u4e88\u6e2c\uff11\uff10\uff1a\u6700\u826f\u306e\u4e88\u6e2c\u30e2\u30c7\u30eb"},"content":{"rendered":"

\u7b2c\uff11\u56de\u3068\u7b2c\uff12\u56de\u306eAmes\/QSAR\u56fd\u969b\u30c1\u30e3\u30ec\u30f3\u30b8\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/a>\u3092\u307e\u3068\u3081\u308b\u3068\u3001\u7dcf\u8a08109\u7a2e\u985e\u306e\u4e88\u6e2c\u7d50\u679c<\/strong><\/span><\/a>\u304c\u63d0\u51fa\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002
\n \u7b2c\uff11\u56de\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306fPhase1,2,3\u306e\uff13\u56de\u306b\u6e21\u3063\u3066\u30b3\u30f3\u30da\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002
\n \u7b2c\uff12\u56de\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\uff11\u56de\u3060\u3051\u3067\u3059\u3002
\n \u4f75\u305b\u3066\uff14\u56de\u306e\u30b3\u30f3\u30da\u304c\u884c\u308f\u308c\u305f\u308f\u3051\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u3067\u4f7f\u7528\u3055\u308c\u305f\u8a55\u4fa1\u7528\u306e\u30d6\u30e9\u30a4\u30f3\u30c9\u30c6\u30b9\u30c8\u30bb\u30c3\u30c8\u306b\u306f\u5404\u56de\u65b0\u898f\u306a\u7d044000\u5316\u5408\u7269\uff08\u7b2c\uff12\u56de\u3067\u306f\u7d041600\u5316\u5408\u7269\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002
\n \u6bce\u56de\u7570\u306a\u308b\u5316\u5408\u7269\u30bb\u30c3\u30c8\u3067\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u8a33\u3067\u3059\u304b\u3089\u3001\u53b3\u5bc6\u306b\u306f\u56de\u3092\u8de8\u3044\u3067\u8a55\u4fa1\u7d50\u679c\u3092\u6bd4\u8f03\u3057\u3066\u826f\u3044\u306e\u304b\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u967d\u6027\u9670\u6027\u306e\u6bd4\u7387\u304c\u307b\u307c\u540c\u7b49\u3067\u5341\u5206\u306a\u5316\u5408\u7269\u6570\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u3089\u306e\u8a55\u4fa1\u7d50\u679c\u306f\u540c\u7b49\u306b\u6bd4\u8f03\u3067\u304d\u308b\u3082\u306e\u3068\u4eee\u5b9a\u3057\u307e\u3059\u3002<\/p>\n

\u3061\u306a\u307f\u306b\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u5831\u544a\u8ad6\u6587\u306e\u4e2d\u3067\u3082\u7570\u306a\u3063\u305f\u30d5\u30a7\u30fc\u30ba\u3001\u56de\u306e\u7d50\u679c\u3092\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\n \u3068\u3044\u3046\u308f\u3051\u3067\u3001\u524d\u7f6e\u304d\u304c\u9577\u304f\u306a\u308a\u307e\u3057\u305f\u304c\u901a\u7b97\u6210\u7e3e\u7b2c\u4e00\u4f4d\u306e\u30e2\u30c7\u30eb<\/span><\/strong>\u3092\u767a\u8868\u3057\u307e\u3059\u3002<\/p>\n

\u7b2c\u4e00\u4f4d\u306f\u3001\u30d0\u30e9\u30f3\u30b9\u7cbe\u5ea6\u3001MCC\u3001F1\u30b9\u30b3\u30a2\u306e\u5168\u3066\u306e\u7dcf\u5408\u6307\u6a19\u3067\u6700\u9ad8\u5024\u3092\u7372\u5f97\u3057\u305f
\n MultiCASE\u793e\u306eBM_PHARMA<\/span> v1.5.2.0 (\u7d71\u8a08\u30d9\u30fc\u30b9)\u3067\u3057\u305f\uff01<\/span><\/strong>
\n \uff08\u30d0\u30e9\u30f3\u30b9\u7cbe\u5ea6=78.9\u3001MCC=0.5\u3001F1\u30b9\u30b3\u30a2=57.9\u3001\u30ab\u30d0\u30fc\u7387=65.3\uff09<\/p>\n

BM_PHARMA\u306e\u7d50\u679c\u306f\u7b2c\uff11\u56de\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u30d5\u30a7\u30fc\u30ba\uff12\u3067\u63d0\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\n \u30c0\u30f3\u30c8\u30c4\u3067\u6587\u53e5\u306a\u304f\u4e00\u756a\u306a\u306e\u3067\u3059\u304c\u300165%\u3068\u304b\u306a\u308a\u4f4e\u3044\u30ab\u30d0\u30fc\u7387\u3068\u306a\u3063\u3066\u3044\u308b\u70b9\u304c\u6c17\u306b\u306a\u308b<\/strong><\/span>\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n

\u5148\u306b\u8ff0\u3079\u3066\u304d\u305f\u3068\u304a\u308a<\/a>\u3001\u3053\u306e\u8a55\u4fa1\u306f\u300c\u30ab\u30d0\u30fc\u7387100%\u306b\u304a\u3051\u308b\u771f\u306e\u30e2\u30c7\u30eb\u306e\u4e88\u6e2c\u6027\u80fd\u300d<\/span><\/strong>\u3068\u300c\u4e88\u6e2c\u9069\u7528\u9818\u57df\uff08\u4e88\u6e2c\u3067\u304d\u308b\u5316\u5408\u7269\uff09\u9078\u629e\u6280\u8853\u300d<\/span><\/strong>\u306e\u4e8c\u3064\u306e\u8981\u56e0\u304b\u3089\u306a\u3063\u3066\u3044\u307e\u3059\u3002
\n \u4e88\u6e2c\u3067\u304d\u306a\u3044\u5316\u5408\u7269\u3068\u3057\u306635%\u306e\u5316\u5408\u7269\u3092\u6392\u9664\u3057\u305f\u3089\u3053\u3093\u306a\u306b\u826f\u3044\u6210\u7e3e\u306b\u306a\u308a\u307e\u3057\u305f\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002
\n \u3053\u306e\u30c1\u30fc\u30e0\uff08\u30b7\u30b9\u30c6\u30e0\uff09\u306e\u6392\u9664\u3059\u308b\u3079\u304d\u5316\u5408\u7269\u3092\u898b\u6975\u3081\u308b\u80fd\u529b\u306f\u7d20\u6674\u3089\u3057\u3044<\/span><\/strong>\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002
\n \u305f\u3076\u3093\u3001\u4e88\u6e2c\u30e2\u30c7\u30eb\u306e\u771f\u306e\u6027\u80fd\u3060\u3063\u3066\u826f\u3044\u306e\u3067\u3057\u3087\u3046\u3002
\n \u3067\u3059\u304c\u3001\u30ab\u30d0\u30fc\u7387100%\u306e\u3068\u304d\u306e\u8a55\u4fa1\u5024\u304c\u4e0d\u660e\u306a\u306e\u3067\u300c\u771f\u306e\u6027\u80fd\u300d<\/span>\u304c\u308f\u304b\u308a\u307e\u305b\u3093<\/span><\/strong>\u3002<\/p>\n

 <\/p>\n

\u3067\u306f\u6b21\u306b\u3001\u30ab\u30d0\u30fc\u7387100%\u3068\u3057\u3066\u63d0\u51fa\u3055\u308c\u305f\u4e88\u6e2c\u30e2\u30c7\u30eb<\/span><\/strong>\u3060\u3051\u3067\u96c6\u8a08\u3092\u884c\u3063\u3066\u307f\u307e\u3059\u3002
\n \u5168109\u7a2e\u306e\u4e88\u6e2c\u30e2\u30c7\u30eb\u306e\u4e2d\u3067\u300133\u30e2\u30c7\u30eb\u304c\u30ab\u30d0\u30fc\u7387100%\u306e\u7d50\u679c\u3092\u63d0\u51fa\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

33\u7a2e\u985e\u306e\u4e2d\u3067\u30d0\u30e9\u30f3\u30b9\u7cbe\u5ea6\u304c\u7b2c\u4e00\u4f4d<\/strong><\/span>\u306e\u30e2\u30c7\u30eb\u306f\u3001
\n \u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u306eMMI-VOTE1\u3067\u3057\u305f\uff01<\/span><\/span><\/strong><\/span>
\n \uff08\u30d0\u30e9\u30f3\u30b9\u7cbe\u5ea6=77.0\u3001MCC=0.44\u3001F1\u30b9\u30b3\u30a2=52.4\u3001\u30ab\u30d0\u30fc\u7387100%\uff09
\n \u307e\u305f\u3001MCC\u3068F1\u30b9\u30b3\u30a2\u304c\u6700\u826f\u306e\u30e2\u30c7\u30eb<\/span><\/strong>\u306f
\n \u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u306eMMI-STK1\u3067\u3057\u305f\uff01<\/span><\/span><\/span><\/span><\/strong>
\n \uff08\u30d0\u30e9\u30f3\u30b9\u7cbe\u5ea6=76.9\u3001MCC=0.44\u3001F1\u30b9\u30b3\u30a2=52.8\u3001\u30ab\u30d0\u30fc\u7387100%\uff09<\/p>\n

\u3053\u308c\u3089\u306e\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u306e\u30e2\u30c7\u30eb\u306f\u7b2c\uff12\u56de\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u63d0\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u3061\u306a\u307f\u306b\u3001\u7b2c\uff12\u56de\u30c1\u30e3\u30ec\u30f3\u30b8\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u306a\u304b\u3067\u306f\u30ab\u30d0\u30fc\u7387\u3092\u4f4e\u304f\u8a2d\u5b9a\u3057\u305f\u3082\u306e\u3092\u542b\u3081\u3066\u3082\u3053\u306e\uff12\u30e2\u30c7\u30eb\u304c\u6700\u512a\u79c0\u3067\u3057\u305f\u304c\u3001\u30e2\u30c7\u30eb\u4f5c\u6210\u8005\u304c\u8a55\u4fa1\u3055\u308c\u308b\u30e2\u30c7\u30eb\u3092\u9078\u629e\u3059\u308b\u3068\u3044\u3046\u30eb\u30fc\u30eb\u306e\u305f\u3081\u306b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30c7\u30fc\u30bf\u3068\u3057\u3066\u30ea\u30f3\u30af\u3055\u308c\u305f\u8868\u306b\u306e\u307f\u6210\u7e3e\u304c\u8f09\u3063\u3066\u3044\u3066\u8ad6\u6587\u672c\u6587\u306b\u306f\u767b\u5834\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u672c\u30d6\u30ed\u30b0\u306e\u6700\u521d\u306b\u7d39\u4ecb<\/a>\u3057\u305f\u3001\u8ad6\u6587\u4e2d\u3067\u6700\u826f\u30e2\u30c7\u30eb\u306e\u4e00\u3064\u3068\u3057\u3066\u8a55\u4fa1\u3055\u308c\u3066\u3044\u305f\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u30e2\u30c7\u30eb\u306f\u4e0a\u8a18\u3068\u306f\u5225\u306e\u3082\u306e\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u3068\u3044\u3046\u308f\u3051\u3067\u3001\u30ab\u30d0\u30fc\u7387100%\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u3067\u306f\u79c1\u305f\u3061\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u306e\u30e2\u30c7\u30eb\u304c\u5727\u52dd<\/span><\/strong>\u3067\u3057\u305f\u3002
\n \u3067\u306f\u3001\u5148\u307b\u3069\u306eMultiCASE\u793e\u306eBM_PHARMA\u3068\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u30e2\u30c7\u30eb\u306e\u300c\u771f\u306e\u6027\u80fd\u300d<\/span>\u306f\u3069\u3061\u3089\u304c\u512a\u308c\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/span>
\n \u3053\u306e\u6bd4\u8f03\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u3001\u5168\u3066\u306e\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u30ab\u30d0\u30fc\u7387\u304c100%\u306e\u3068\u304d\u306e\u8a55\u4fa1\u7d50\u679c\u3092\u89e3\u6790\u7684\u306b\u63a8\u5b9a<\/span><\/strong>\u3057\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

 <\/p>\n

\uff08\u3053\u308c\u304b\u3089\u8ff0\u3079\u308b\u4e88\u5b9a\u306e\u89e3\u6790\u5185\u5bb9\u306f\u30d7\u30ec\u30d7\u30ea\u30f3\u30c8\u30b5\u30fc\u30d0\u30fc\u306b\u516c\u958b<\/a>\u3057\u3066\u3044\u307e\u3059\u3002\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7b2c\uff11\u56de\u3068\u7b2c\uff12\u56de\u306eAmes\/QSAR\u56fd\u969b\u30c1\u30e3\u30ec\u30f3\u30b8\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u307e\u3068\u3081\u308b\u3068\u3001\u7dcf\u8a08109\u7a2e\u985e\u306e\u4e88\u6e2c\u7d50\u679c\u304c\u63d0\u51fa\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002 \u7b2c\uff11\u56de\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306fPhase1,2,3\u306e\uff13\u56de\u306b\u6e21\u3063\u3066\u30b3\u30f3\u30da\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002 […]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[18],"tags":[20,21],"class_list":["post-2782","post","type-post","status-publish","format-standard","hentry","category-blog","tag-ames","tag-qsar"],"_links":{"self":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts\/2782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/comments?post=2782"}],"version-history":[{"count":0,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts\/2782\/revisions"}],"wp:attachment":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/media?parent=2782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/categories?post=2782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/tags?post=2782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}