{"id":3074,"date":"2024-03-12T00:27:09","date_gmt":"2024-03-11T15:27:09","guid":{"rendered":"https:\/\/u-lab.my-pharm.ac.jp\/~mminfo\/?p=3074"},"modified":"2024-03-12T00:27:09","modified_gmt":"2024-03-11T15:27:09","slug":"chat-ai%e3%81%af%e8%96%ac%e5%89%a4%e5%b8%ab%e5%9b%bd%e5%ae%b6%e8%a9%a6%e9%a8%93%e3%81%ae%e5%95%8f%e9%a1%8c%e3%82%92%e8%a7%a3%e3%81%91%e3%82%8b%e3%81%ae%e3%81%8b%ef%bc%9f%ef%bc%882%ef%bc%89","status":"publish","type":"post","link":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/blog\/3074\/","title":{"rendered":"Chat AI\u306f\u85ac\u5264\u5e2b\u56fd\u5bb6\u8a66\u9a13\u306e\u554f\u984c\u3092\u89e3\u3051\u308b\u306e\u304b\uff1f\uff08ChatGPT\u3068Consensus\uff09"},"content":{"rendered":"<p>ChatGPT\u3092\u3046\u307e\u304f\u4f7f\u3063\u3066\u56fd\u5bb6\u8a66\u9a13\u306e\u554f\u984c\u306e\u6b63\u7b54\u7387\u3092\u4e0a\u3052\u3089\u308c\u306a\u3044\u304b\u5c11\u3057\u8a66\u884c\u932f\u8aa4\u3057\u3066\u307f\u307e\u3057\u305f\u3002<br \/>\n \u305d\u306e\u7d50\u679c\u3001\u79d1\u5b66\u7814\u7a76\u306e\u9818\u57df\u3067\u306e\u6587\u732e\u691c\u7d22\u7b49\u3067\u8a55\u5224\u306e\u826f\u3044GPTs\u3067\u3042\u308b\u300c<span style=\"color: #ff0000;\"><strong>Consensus<\/strong><\/span>\u300d\u3092\u4f7f\u3046\u3068\u4e0a\u624b\u304f\u3044\u304d\u305d\u3046\u306a\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u304a\u984c\u306f\u7b2c109\u56de\u85ac\u5264\u5e2b\u56fd\u5bb6\u8a66\u9a13\u306e\u554f174\uff08\u85ac\u5264\u5b66\u5206\u91ce\u306e\u7406\u8ad6\u554f\u984c\uff09\u306e\u9078\u629e\u80a22\u3067\u3059\u3002<\/p>\n<p><span style=\"background-color: #ccffff;\">\u300cCYP2D6\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u95a2\u4e0e\u3059\u308b\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306epoor metabolizer(PM)\u3067\u306f\u3001\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u3044\u3002 \u300d<span style=\"background-color: #ffffff;\">\u306e\u6b63\u8aa4\u554f\u984c\u3067\u3059\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u89e3\u7b54\u306f\u300c\u6b63\u300d\u3067\u3059\u304c\u3001ChatGPT-4\u3001Gemini Ultra\u3001Claude3 Opus\u306e\u5168\u54e1\u304c\u300c\u8aa4\u300d\u3068\u5224\u5b9a\u3057\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002<br \/>\n \u5f7c\u3089\u306e\u89e3\u8aac\u3092\u8aad\u3080\u3068\u3001CYP2D6\u304c\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u6d3b\u6027\u4ee3\u8b1d\u7269\u3078\u306e\u4ee3\u8b1d\u3092\u89e6\u5a92\u3059\u308b\u3068\u8aa4\u89e3\u3057\u3066\u3044\u305f\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n \u3053\u306e\u554f\u984c\u306e\u89e3\u7b54\u306b\u306f\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u4ee3\u8b1d\u306b\u5bfe\u3059\u308b\u3082\u3046\u4e00\u6bb5\u968e\u6df1\u3044\u7406\u89e3\u304c\u5fc5\u8981\u3067\u3059\u3002<br \/>\n \u305d\u3053\u3067\u3001Consensus\u3092\u4f7f\u3063\u3066\u52c9\u5f37\u3055\u305b\u306a\u304c\u3089\u554f\u984c\u3092\u89e3\u304b\u305b\u3066\u307f\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"background-color: #ffffff; color: #0000ff;\">User<\/span><\/strong><\/p>\n<p><span style=\"background-color: #ccffff;\">\u300cCYP2D6\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u95a2\u4e0e\u3059\u308b\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306epoor metabolizer(PM)\u3067\u306f\u3001\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u3044\u3002 \u300d<\/span><br \/>\n <span style=\"background-color: #ccffff;\">\u4e0a\u8a18\u306e\u6587\u8a00\u306f\u8a66\u9a13\u306b\u304a\u3044\u3066\u6b63\u8aa4\u3092\u554f\u308f\u308c\u3066\u3044\u308b\u9078\u629e\u80a2\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/span><br \/>\n <span style=\"background-color: #ccffff;\">\u691c\u7d22\u3057\u3066\u8abf\u67fb\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u305d\u306e\u969b\u3001\u307e\u305a\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u751f\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u8abf\u67fb\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ffffff;\"><strong><span style=\"color: #ff0000;\">GPT<\/span><\/strong><\/span><\/p>\n<p><span style=\"background-color: #ff99cc;\">CYP2D6\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306f\u3001\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u3088\u3046\u306a\u4e09\u74b0\u7cfb\u6297\u3046\u3064\u85ac\u3092\u542b\u3080\u69d8\u3005\u306a\u85ac\u7269\u306e\u4ee3\u8b1d\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3002CYP2D6\u9175\u7d20\u306f\u591a\u304f\u306e\u85ac\u7269\u306e\u4ee3\u8b1d\u3092\u62c5\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u6d3b\u6027\u306f\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u308a\u500b\u4eba\u9593\u3067\u5927\u304d\u304f\u7570\u306a\u308b\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u3001\u500b\u4eba\u3092\u4ee3\u8b1d\u4e0d\u826f\u578b\uff08PM\uff09\u3001\u4e2d\u9593\u578b\uff08IM\uff09\u3001\u5e83\u7bc4\u56f2\u578b\uff08EM\uff09\u3001\u8d85\u901f\u4ee3\u8b1d\u578b\uff08UM\uff09\u3068\u3044\u3046\u7570\u306a\u308b\u4ee3\u8b1d\u8868\u73fe\u578b\u306b\u5206\u985e\u3057\u3001\u85ac\u52b9\u3068\u5b89\u5168\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ff99cc;\">\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306f\u4e3b\u306bCYP2C19\u306b\u3088\u3063\u3066\u6d3b\u6027\u4ee3\u8b1d\u7269\u3067\u3042\u308b\u30c7\u30b7\u30d7\u30e9\u30df\u30f3\u306b\u4ee3\u8b1d\u3055\u308c\u308b\u3002\u305d\u306e\u5f8c\u3001CYP2D6\u304c\u3055\u3089\u306b\u30c7\u30b7\u30d7\u30e9\u30df\u30f3\u3092\u4ee3\u8b1d\u3059\u308b\u3002CYP2D6\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306f\u9175\u7d20\u6d3b\u6027\u306e\u5909\u52d5\u306b\u3064\u306a\u304c\u308a\u3001\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3002\u907a\u4f1d\u5b50\u5909\u7570\u306e\u305f\u3081\u306b\u9175\u7d20\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u304b\u3001\u3042\u308b\u3044\u306f\u5168\u304f\u306a\u3044\u3053\u3068\u3092\u7279\u5fb4\u3068\u3059\u308bCYP2D6 PM\u306e\u8868\u73fe\u578b\u3092\u6301\u3064\u500b\u4f53\u3067\u306f\u3001\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u4ee3\u8b1d\u304c\u5927\u304d\u304f\u5f71\u97ff\u3055\u308c\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u4eba\u306f\u3001CYP2D6\u6d3b\u6027\u304c\u6b63\u5e38\u306a\u4eba\u306b\u6bd4\u3079\u3066\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6709\u52b9\u6027\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304c\u3001\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3082\u9ad8\u304f\u306a\u308b\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ff99cc;\">\u7814\u7a76\u306b\u3088\u308b\u3068\u3001CYP2D6\u306e\u591a\u578b\u306f\u5b9f\u969b\u306b\u4ee3\u8b1d\u80fd\u529b\u3092\u7570\u306a\u3089\u305b\u3001\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u3088\u3046\u306a\u85ac\u7269\u306e\u85ac\u7269\u52d5\u614b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001\u3042\u308b\u7a2e\u306eCYP2D6\u5909\u7570\u4f53\u3092\u6301\u3064\u4eba\u306f\u3001\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u4ee3\u8b1d\u304c\u5909\u5316\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u6d3b\u6027\u4ee3\u8b1d\u7269\u3067\u3042\u308b\u30c7\u30b7\u30d7\u30e9\u30df\u30f3\u306e\u6fc3\u5ea6\u304c\u7570\u306a\u308a\u3001\u85ac\u5264\u306e\u6cbb\u7642\u52b9\u679c\u3084\u526f\u4f5c\u7528\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\uff08Clinical Pharmacology &amp; Therapeutics, 2013; Drug Metabolism and Disposition, 2007; British Journal of Clinical Pharmacology, 2002\uff09\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ff99cc;\">\u3057\u305f\u304c\u3063\u3066\u3001\u300cCYP2D6\u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u308b\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306e\u4ee3\u8b1d\u4e0d\u826f\u8005\uff08PM\uff09\u3067\u306f\u3001\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u3044\u300d\u3068\u3044\u3046\u8a18\u8ff0\u306f\u6b63\u78ba\u3067\u3042\u308b\u3002\u3053\u308c\u306f\u3001PM\u306b\u304a\u3044\u3066\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u3092\u52b9\u7387\u7684\u306b\u4ee3\u8b1d\u3059\u308b\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u30c7\u30b7\u30d7\u30e9\u30df\u30f3\u306e\u3088\u3046\u306a\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u3002CYP2D6\u5909\u7570\u4f53\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u30a4\u30df\u30d7\u30e9\u30df\u30f3\u306b\u5bfe\u3059\u308b\u500b\u3005\u306e\u53cd\u5fdc\u3092\u4e88\u6e2c\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u3001\u6cbb\u7642\u6210\u7e3e\u3092\u6700\u9069\u5316\u3057\u526f\u4f5c\u7528\u3092\u6700\u5c0f\u5316\u3059\u308b\u305f\u3081\u306e\u7528\u91cf\u8abf\u7bc0\u306e\u6307\u91dd\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n<p>\uff08\u6a5f\u68b0\u7ffb\u8a33\u6e08\u307f\uff09\u6ce8\uff1a\u3053\u308c\u306fAI\u304c\u51fa\u529b\u3057\u305f\u30c6\u30ad\u30b9\u30c8\u3067\u3059<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u7121\u4e8b\u6b63\u89e3\u306b\u305f\u3069\u308a\u7740\u304d\u307e\u3057\u305f\u3002<br \/>\n \u304a\u307e\u3051\u306b\u6839\u62e0\u3068\u306a\u308b\u5f15\u7528\u6587\u732e\u3082\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u89e3\u7b54\u3092\u3053\u306e\u3088\u3046\u306a\u6b63\u7b54\u306b\u8a98\u5c0e\u3059\u308b\u306b\u306f\u3001\u300c\u305d\u306e\u969b\u3001\u307e\u305a\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u751f\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u8abf\u67fb\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u300d\u306e\u3088\u3046\u306a\u554f\u984c\u306e\u610f\u56f3\u3092\u7406\u89e3\u3057\u305f\u4e0a\u3067\u306e\u8cea\u554f\u5185\u5bb9\u3092\u52a0\u3048\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n \u5c11\u306a\u304f\u3068\u3082\u73fe\u72b6\u3067\u306f\u8cea\u554f\u8005\u306e\u30b9\u30ad\u30eb\u3084\u77e5\u8b58\u304c\u89e3\u7b54\u306e\u8cea\u3092\u5927\u304d\u304f\u5de6\u53f3\u3057\u3066\u3057\u307e\u3046\u3088\u3046\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ChatGPT\u3092\u3046\u307e\u304f\u4f7f\u3063\u3066\u56fd\u5bb6\u8a66\u9a13\u306e\u554f\u984c\u306e\u6b63\u7b54\u7387\u3092\u4e0a\u3052\u3089\u308c\u306a\u3044\u304b\u5c11\u3057\u8a66\u884c\u932f\u8aa4\u3057\u3066\u307f\u307e\u3057\u305f\u3002 \u305d\u306e\u7d50\u679c\u3001\u79d1\u5b66\u7814\u7a76\u306e\u9818\u57df\u3067\u306e\u6587\u732e\u691c\u7d22\u7b49\u3067\u8a55\u5224\u306e\u826f\u3044GPTs\u3067\u3042\u308b\u300cConsensus\u300d\u3092\u4f7f\u3046\u3068\u4e0a\u624b\u304f\u3044\u304d\u305d\u3046\u306a\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057 [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[18],"tags":[22,23,24],"class_list":["post-3074","post","type-post","status-publish","format-standard","hentry","category-blog","tag-chatgpt","tag-ai","tag-24"],"_links":{"self":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts\/3074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/comments?post=3074"}],"version-history":[{"count":0,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/posts\/3074\/revisions"}],"wp:attachment":[{"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/media?parent=3074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/categories?post=3074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/u-lab2.my-pharm.ac.jp\/~mminfo\/wp-json\/wp\/v2\/tags?post=3074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}